Downstream development and Kona low genesis

KONA Powder and Particle Journal No. 34 (2017) 3–23/Doi:10.14356/kona.2017004

There is great demand for nanoparticles (NPs) dispersed in liquid phases for practical applications of functional NP materials. However, it is difficult to produce NP dispersions with specific particle sizes, concentrations, viscosities, and purities on an industrial scale (large mass production rate and low energy consumption). In this review, we highlight recent developments in NP dispersion ...

KONA Powder and Particle Journal No. 33 (2016) 340–353/Doi:10.14356/kona.2016025

Generally, indium-tin-oxides (ITO) thin film is prepared by the sputtering process with ITO target, but only 20 % of ITO yielded from the target is deposited on the substrate. Namely, about 80 % ITO is exhausted by the deposition elsewhere far from the substrate. The recycling process of indium is limited so that ca. 20 % ITO of the starting material is lost without any recovery. Even if the re...

KONA Powder and Particle Journal No. 33 (2016) 63–85/Doi:10.14356/kona.2016014

This article reviews the pulmonary route of administration, aerosol delivery devices, characterization of pulmonary drug delivery systems, and discusses the rationale for inhaled delivery of siRNA. Diseases with known protein malfunctions may be mitigated through the use of siRNA therapeutics. The inhalation route of administration provides local delivery of siRNA therapeutics for the treatment...

KONA Powder and Particle Journal No. 34 (2017) 44–69/Doi:10.14356/kona.2017005

In this article, applications of engineered nanoparticles containing siRNA for inhalation delivery are reviewed and discussed. Diseases with identified protein malfunctions may be mitigated through the use of well-designed siRNA therapeutics. The inhalation route of administration provides local delivery of siRNA therapeutics to the lungs for various pulmonary diseases. A siRNA delivery system ...

Downstream Impacts of Pakihi Development